Precise measurements of the solubility of sulphadiazine in water, dimethylformamide (DMF), and a range of mixtures of these solvents have been made at 20°, 30°, and 40°. The solubility of sulphadiazine in the mixtures increases with their DMF content. The partial molar heats and entropies of solution decrease with increasing DMF concentration.
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Elworthy et al. (1968) studied this question.