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December 7, 2007The Journal of Gene Medicine

AAV‐mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes

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Why the study?

Does AAV-mediated knockdown of phospholamban improve contractility and calcium handling in cardiomyocytes?

Population

Cultured cardiomyocytes and mice

Design

Preclinical

Key result

AAV-delivered shRNAs targeting phospholamban significantly reduced PLN levels and improved contractility and calcium handling in cultured cardiomyocytes and mouse hearts.

Authors

LALourdes M. AndinoMTMorihiko TakedaHKHideko Kasahara

Discussion

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Overview

May support AAV-shRNA development for heart failure; leaves open translation from mouse models to clinical use.

Structured PICO

Does AAV-mediated knockdown of phospholamban improve contractility and calcium handling in cardiomyocytes?

P
Population
Cultured cardiomyocytes and mice
I
Intervention
AAV-mediated delivery of small hairpin RNAs (shRNAs) targeting phospholamban (PLN)
O
Outcome
PLN mRNA and protein levels, free cytosolic calcium, and contractile properties (cell shortening and relaxation)surrogate

AAV-mediated knockdown of phospholamban improves contractility and calcium handling in cardiomyocytes, offering a potential therapeutic strategy for chronic heart failure.

Cite This Study

Andino et al. (2007) studied chronic heart failure. AAV-delivered small hairpin RNAs (shRNAs) targeting phospholamban was evaluated on PLN RNA and protein levels, cell shortening, relaxation, and calcium decay. AAV-delivered shRNAs targeting phospholamban significantly reduced PLN levels and improved contractility and calcium handling in cultured cardiomyocytes and mouse hearts.

synapsesocial.com/papers/6a883004580ea41f0158381bhttps://doi.org/10.1002/jgm.1131
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction2000 · 89 citations
  2. 2Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines2011 · 53 citations
  3. 3A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum2014 · 23 citations
  4. 4A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation2004 · 42 citations
  5. 5Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats2004 · 17 citations