Lithium-Induced Hyperparathyroidism: An Alteration of the "Set-Point"

Brief Reports1 January 1982Lithium-Induced Hyperparathyroidism: An Alteration of the "Set-Point"FU-HSIUNG SHEN, M.D., Ph.D., DONALD J. SHERRARD, M.D.FU-HSIUNG SHEN, M.D., Ph.D., DONALD J. SHERRARD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-63 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypercalcemia with elevated circulating parathyroid hormone (PTH) levels occurs in some patients treated with lithium for manic-depressive disorders (1-4). In the first few cases described, surgery was the preferred approach: The neck was explored, the alleged "adenoma" removed, and the patients presumably "cured" (2). In more recent studies the benign nature of this condition has been recognized and a more conservative attitude adopted (3). Despite these changes in approach, the underlying pathophysiologic characteristics of the disorder remain obscure.We have seen a patient with this condition since 1975. The concurrent use of diuretics, furosemide or hydrochlorothiazide, for hypertension gave us...REFERENCES1. CERVI-SKINNER S. Lithium carbonate induced hypercalcemia. West J Med. 1977;127:527-8. MedlineGoogle Scholar2. CHRISTENSSON T. Lithium, hypercaleaemia and hyperparathyroidism. Lancet. 1976;2:144. Letter. CrossrefMedlineGoogle Scholar3. CHRISTIANSEN C, BAASTRUP P, LINDGREEN P, and TRANSBOI I. Endocrine effect of lithium: II. "Primary hyperparathyroidism." Acta Endocrinol (Copenh). 1978;88:528-34. CrossrefMedlineGoogle Scholar4. CHRISTIANSEN C, BAASTRUP P, and TRANSBOL I. Development of "primary" hyperparathyroidism during lithium therapy: longitudinal study. Neuropsychobiology. 1980;6:280-3. CrossrefMedlineGoogle Scholar5. KRUTZIK S. Parathyroid hormone. In: Nichols Institute Radioimmunoassay Manual. San Pedro, California. Nichols Institute; 1977:105-12. Google Scholar6. MURRAY T, PEACOCK M, POWELL D, MONCHIK J, and POTTS J. Non-autonomy of hormone secretion in primary hyperparathyroidism. Clin Endocrinol. 1972;1:235-46. CrossrefMedlineGoogle Scholar7. BROWN E. Lithium induces abnormal calcium-regulated PTH release in dispersed bovine parathyroid cells. Clin Res. 1980;28:646A. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FU-HSIUNG SHEN, M.D., Ph.D.; DONALD J. SHERRARD, M.D.Affiliations: University of Washington and Veterans Administration Medical Center Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Related HypercalcemiaSurgical Management of Multiglandular Parathyroid DiseaseNephrotoxicity of Lithium and Drugs of AbuseDrug and Hormone Effects on Vitamin D MetabolismPrimary HyperparathyroidismThe Prevalence of Lithium-Associated Hyperparathyroidism in a Large Swedish Population Attending Psychiatric Outpatient UnitsLithium-Associated Hyperparathyroidism: A Pooled AnalysisLithium-associated hyperparathyroidism and hypercalcaemia: A case-control cross-sectional studyThe management of primary hyperparathyroidismLithium-associated hypercalcemia and hyperparathyroidism in the elderly: What do we know?Drug and Hormone Effects on Vitamin D MetabolismLithium Associated Hyperparathyroidism: An Evidence Based Surgical ApproachNephrotoxicity of Lithium and Drugs of AbuseLithium Therapy and Hyperparathyroidism: An Evidence-Based AssessmentLithium-associated kidney effectsEndocrine and Metabolic Adverse Effects of Psychotropic Medications in Children and AdolescentsReversible Hypercalcemia and Hyperparathyroidism Associated With Lithium Therapy: Case Report and Review of LiteratureDrug and Hormone Effects on Vitamin D MetabolismPathology and outcome of surgical treatment for lithium-associated hyperparathyroidismLithium-induced renal effectsHyperparathyroïdie induite par le lithium. 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