Key result
Early type 1 diabetic cardiomyopathy in the Akita mouse model is characterized by diastolic dysfunction and lipotoxicity with preserved systolic function, which is reversed by insulin treatment.
Population
Male Ins2WT/C96Y mice and their littermate control mice at 3 and 6 months of age
Comparison
Insulin treatment vs Littermate control mice; untreated Ins2WT/C96Y…
Design
Preclinical
Follow-up
Evaluated at 3 and 6 months of age
Authors
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Hypothesis-generating for insulin-reversible lipotoxic diastolic dysfunction in type 1 diabetes models; leaves open translation to human cardiomyopathy.
Early type 1 diabetic cardiomyopathy in the Akita mouse model is characterized by lipotoxic cardiomyopathy and diastolic dysfunction with preserved systolic function, which is reversible with insulin treatment.
Basu et al. (2009) studied Type 1 diabetic cardiomyopathy. Ins2WT/C96Y mutation (Type 1 diabetes model) vs. Ins2WT/WT littermate controls was evaluated on Cardiac systolic and diastolic function, and myocardial lipotoxicity/fibrosis. Early type 1 diabetic cardiomyopathy in the Akita mouse model is characterized by diastolic dysfunction and lipotoxicity with preserved systolic function, which is reversed by insulin treatment.