What is the clinical evidence from this study?

Study design: Observational. Population: Anabolic steroid use in resistance-trained males (n=13). Intervention: Anabolic steroid use vs. Non-anabolic steroid users. Primary outcome: Early diastolic tissue velocity (E') post-exercise (95% CI 0.01-0.02, p=0.041).

July 3, 2018Science & SportsOpen Access

Acute cardiovascular responses to resistance exercise in anabolic steroids users: A preliminary investigation

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Key result

Anabolic steroid use did not significantly alter the acute cardiovascular and biomarker responses to a high-intensity resistance exercise session compared to non-users.

Why the study?

Does a single bout of resistance exercise alter acute echocardiographic and biomarker responses in anabolic steroid users compared to non-users?

Population

13 resistance-trained males aged 18-50 years with a minimum of 2 years resistance training.

Comparison

A single high-intensity full-body resistance… vs Non-anabolic steroid users undergoing the same…

Design

Cohort

Follow-up

15 minutes post-exercise

Authors

PAPeter Angell DGDaniel J. Green RLRachel N. Lord

Discussion

Member takes

Overview

Single-session resistance exercise shows no acute cardiac exacerbation in steroid users; hypothesis-generating, needing longitudinal confirmation before practice implications.

Study Design

Type

Observational (n=13)

Multicenter

Structured PICO

Does a single bout of resistance exercise alter acute echocardiographic and biomarker responses in anabolic steroid users compared to non-users?

Population

13 resistance-trained males (7 anabolic steroid users and 6 non-users) aged 18-50 underwent a single high-intensity resistance exercise session to assess acute cardiovascular responses.

Exposure

A single high-intensity full-body resistance exercise session (approximately 70 minutes, 8-12 reps for 3 sets with one-minute rest between sets).

Comparator

Non-anabolic steroid users undergoing the same resistance exercise session.

Outcome

Echocardiographic measures of cardiac function and cardiac biomarkers (cTnI, NT-proBNP) assessed at 15 minutes post-exercise.surrogate

Main Result

Absolute Event Rate: 11% vs 12%

p-value: p=0.041

A single bout of high-intensity resistance exercise does not exacerbate acute cardiac dysfunction or biomarker release in anabolic steroid users compared to non-users.

Limitations

Limited sample size
Heterogeneity of subjects including variations in age, training status and diet
Inter and intra-individual differences in AS dose and history
Small sample size and possible self-selection bias
Lack of left atrial volume measures
Limited blood sampling points and lack of serum testosterone measurement

Cite This Study

Angell et al. (2018) conducted an observational in Anabolic steroid use in resistance-trained males (n=13). Anabolic steroid use vs. Non-anabolic steroid users was evaluated on Early diastolic tissue velocity (E') post-exercise (95% CI 0.01-0.02, p=0.041). Anabolic steroid use did not significantly alter the acute cardiovascular and biomarker responses to a high-intensity resistance exercise session compared to non-users.

synapsesocial.com/papers/6a8832e10562fa470f4a698d https://doi.org/10.1016/j.scispo.2018.05.003

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July 3, 2018Science & SportsOpen Access

Acute cardiovascular responses to resistance exercise in anabolic steroids users: A preliminary investigation

View Full Paper

Ask AI

Bookmark

Key result

Anabolic steroid use did not significantly alter the acute cardiovascular and biomarker responses to a high-intensity resistance exercise session compared to non-users.

Why the study?

Does a single bout of resistance exercise alter acute echocardiographic and biomarker responses in anabolic steroid users compared to non-users?

Population

13 resistance-trained males aged 18-50 years with a minimum of 2 years resistance training.

Comparison

A single high-intensity full-body resistance… vs Non-anabolic steroid users undergoing the same…

Design

Cohort

Follow-up

15 minutes post-exercise

Authors

PAPeter Angell DGDaniel J. Green RLRachel N. Lord

Discussion

Member takes

Overview

Single-session resistance exercise shows no acute cardiac exacerbation in steroid users; hypothesis-generating, needing longitudinal confirmation before practice implications.

Study Design

Type

Observational (n=13)

Multicenter

Structured PICO

Does a single bout of resistance exercise alter acute echocardiographic and biomarker responses in anabolic steroid users compared to non-users?

Population

13 resistance-trained males (7 anabolic steroid users and 6 non-users) aged 18-50 underwent a single high-intensity resistance exercise session to assess acute cardiovascular responses.

Exposure

A single high-intensity full-body resistance exercise session (approximately 70 minutes, 8-12 reps for 3 sets with one-minute rest between sets).

Comparator

Non-anabolic steroid users undergoing the same resistance exercise session.

Outcome

Echocardiographic measures of cardiac function and cardiac biomarkers (cTnI, NT-proBNP) assessed at 15 minutes post-exercise.surrogate

Main Result

Absolute Event Rate: 11% vs 12%

p-value: p=0.041

A single bout of high-intensity resistance exercise does not exacerbate acute cardiac dysfunction or biomarker release in anabolic steroid users compared to non-users.

Limitations

Limited sample size
Heterogeneity of subjects including variations in age, training status and diet
Inter and intra-individual differences in AS dose and history
Small sample size and possible self-selection bias
Lack of left atrial volume measures
Limited blood sampling points and lack of serum testosterone measurement

Cite This Study

synapsesocial.com/papers/6a8832e10562fa470f4a698d https://doi.org/10.1016/j.scispo.2018.05.003

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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