Average Coronary Blood Flow Per Unit Weight of Left Ventricle in Patients With and Without Coronary Artery Disease
Why the study?
Is average left ventricular flow per unit mass reduced at rest in patients with advanced coronary artery disease compared to normal individuals?
Population
46 individuals, comprising 20 normal individuals and 26 patients with arteriographically proven, advanced…
Comparison
Measurement of average left ventricular flow per… vs Normal individuals and traditional nitrous oxide…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Associates advanced CAD with reduced resting LV flow per mass; hypothesis-generating for perfusion as biomarker or target.
Structured PICO
Is average left ventricular flow per unit mass reduced at rest in patients with advanced coronary artery disease compared to normal individuals?
P
Population
46 individuals, comprising 20 normal individuals and 26 patients with arteriographically proven, advanced coronary artery disease. Preliminary studies were also conducted in a canine model.
I
Intervention
Measurement of average left ventricular flow per unit mass (F/W) using modified inert gas techniques with helium as a tracer
C
Comparator
Normal individuals (for the CAD group) and traditional nitrous oxide and krypton techniques
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Outcome
Average left ventricular flow per unit mass (F/W) at restsurrogate
Modified inert gas techniques using helium demonstrate that patients with advanced coronary artery disease have significantly reduced resting left ventricular myocardial blood flow compared to normal individuals.
Cite This Study
Klocke et al. (1974) studied this question.