A new DNA probe assay (PACE 2, Gen-probe) was compared with cell culture for the detection of Chlamydia trachomatis in 909 women attending the Royal Women's Hospital, Melbourne, Victoria. The DNA probe assay had a sensitivity of 86.2%, a specificity of 99.9% and a positive predictive value of 96.2% in a population with 3.2% prevalence, indicating that it may be a suitable alternative to culture for the detection of C. trachomatis in specimens from the genital tract.
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Lees et al. (1991) studied this question.
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