1 Differences in the base ratios would be reflected as differences in the nartial snecific volume.B, of the DNA molecules.Since the term (1 -6~) appears in the equation for the sedimentation coefficient, S, a 4% difference in B would cause a difference of about 5% in S, in a dilute salt solution of density p = 1.0.See reference 4 for a detailed report on the partial specific volume of various DNA samples and inhomogeneity in base ratio.
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Schumaker et al. (1960) studied this question.
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