Ultra-Wide–Field Green-Light (532-nm) Autofluorescence Imaging in Chronic Vogt-Koyanagi-Harada Disease

BACKGROUND AND OBJECTIVE: To assess the prevalence of peripheral fundus autofluorescence (FAF) abnormalities in chronic Vogt-Koyanagi-Harada disease (VKH). PATIENTS AND METHODS: A retrospective review of cases at the Doheny Eye Institute between December 2009 and April 2010. Patients with chronic VKH who had ultra-wide-field FAF and pseudo-color imaging performed were included. All images were reviewed independently by two reading center certified retina specialists. RESULTS: Twenty eyes of 10 patients were included in this analysis. Fourteen eyes of 7 patients (70%) showed peripheral changes on FAF images outside the posterior pole. Three different patterns were observed: multifocal hypofluorescent spots (n = 11 eyes), hyperfluorescent spots (n = 8 eyes), and a unique lattice-like pattern in both eyes of one patient. There were noticeable disparities between FAF and color images. CONCLUSION: Peripheral FAF abnormalities are frequent in chronic VKH and are readily revealed by wide-field FAF imaging and manifesting with distinct patterns. Further investigation in prospective studies is warranted.