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A facile method of preparing triple-modality, optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs.
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Park et al. (2010) studied this question.
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