Key result
HnRNP K mislocalisation from the nucleus to the cytoplasm in pyramidal neurons of the frontal cortex is a frequent neuropathological feature in frontotemporal lobar degeneration and ageing, leading to widespread changes in splicing including cryptic exon inclusion.
Why the study?
Pathological redistribution of hnRNP K to the cytoplasm had been linked to several malignancies but remained underexplored in neurodegenerative disease.
Observational (n=96)
Yes
p-value: p=0.004
HnRNP K mislocalisation is a novel neuropathological feature in FTLD and ageing that leads to widespread changes in splicing, including cryptic exon inclusion.
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Hypothesis-generating for HnRNP K in FTLD; human studies needed before clinical relevance.
Bampton et al. (2021) conducted an observational in Frontotemporal lobar degeneration (FTLD) (n=96). Frontotemporal lobar degeneration (FTLD) vs. Neurologically normal controls was evaluated on Proportion of sampled images with at least one neuron exhibiting hnRNP K mislocalisation (p=0.004). HnRNP K mislocalisation from the nucleus to the cytoplasm in pyramidal neurons of the frontal cortex is a frequent neuropathological feature in frontotemporal lobar degeneration and ageing, leading to widespread changes in splicing including cryptic exon inclusion.
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