Our model of the active site of the sweet taste receptor, defined by means of several rigid molds, such as saccharines and naphthimidazolesulfonic acids, already consistent with many classes of rigid and flexible sweeteners, is shown to be consistent also with the so‐called hypersweet molecules, notably guanidino‐acids and arylureido‐dipeptides, and with the crystal‐state structures of two conformationally restricted analogues of aspartame, alitame and [L‐(αMe)Phe] 2 aspartame, that have been recently determined.
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Kamphuis et al. (1992) studied this question.
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