Key result
The C825T polymorphism of the β3 subunit of G-protein was not significantly associated with the occurrence of vasovagal syncope.
Why the study?
Does the C825T polymorphism of the β3 subunit of G-protein influence the occurrence of vasovagal syncope or autonomic nervous system response during a head-up tilt test?
Case-Control (n=266)
No
Does the C825T polymorphism of the β3 subunit of G-protein influence the occurrence of vasovagal syncope or autonomic nervous system response during a head-up tilt test?
The C825T polymorphism of the β3 subunit of G-protein is not associated with the occurrence of vasovagal syncope, though it may influence parasympathetic and sympathetic responses during orthostatic stress.
No association with vasovagal syncope in case-control data; leaves open any role in autonomic responses during tilt testing.
OBJECTIVES: The aim of this prospective study was to investigate the impact of genetic polymorphisms of β3 subunit of G-protein on the occurrence of vasovagal syncope, hemodynamic parameters and heart rate variability during head-up tilt test (HUT). BACKGROUND: G-proteins play an important role in the intracellular transmission of impulses in cardiovascular autonomic reflexes. METHODS: In 157 patients with suspected vasovagal syncope HUT was performed. Ninety-one patients (38 men, 53 women, mean age 48 ± 17 years) had positive HUT. Control group consisted of 109 subjects (69 men, 40 women, mean age 37 ± 16 years) with no history of syncope. Results of HUT, hemodynamic parameters and LF, HF, LF/HF, SDNN, RMSSD parameters of heart rate variability were compared in patients with different genotypes. C825T polymorphism of β3 subunit of G-protein was determined in the study subjects. RESULTS: There was no significant difference in the distribution of genotypes between patients and control group. Also, there was no significant difference in hemodynamic parameters. A statistically significant difference was found between genotypes in LF/HF in the early HUT (mean rank CC: 48.68 vs CT: 35.51 vs TT: 34.14; p = 0.039) and at RMSSD at the time of syncope (mean rank CC: 32.38 vs CT: 42.74 vs TT: 18.50; p = 0.026). CONCLUSIONS: In this study, the relation of C825T polymorphism of β3 subunit of G-protein to vasovagal syncope was not documented (Tab. 2, Fig. 4, Ref. 37).
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Evin et al. (2016) conducted a case-control in Vasovagal syncope (n=266). C825T polymorphism of β3 subunit of G-protein vs. Healthy controls was evaluated on Distribution of C825T polymorphism genotypes between patients and controls (p=ns). The C825T polymorphism of the β3 subunit of G-protein was not significantly associated with the occurrence of vasovagal syncope.
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