A key intermediate in porphyrin and corrin biosynthesis is the trisubstituted pyrrole porphobilinogen (PBG). The fate of PBG in the biosynthesis of porphyrins and corrins has been monitored by NMR spectroscopy in vivo and in vitro employing various nuclei. The syntheses of highly tritiated PBG and its immediate precursor 5‐aminolevulinic acid (ALA) are reported, together with 3 H, 1 H and 13 C assignments.
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Evans et al. (1985) studied this question.
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