Key result
Iron deficiency anemia was present in 72% of heart failure patients and was associated with significantly higher NTpro-BNP levels compared to patients with normal iron levels (P<0.01).
Why the study?
The study was conducted to assess the prevalence of nutritional anemia in heart failure patients and evaluate its correlation with serum levels of NT-pro BNP.
Observational (n=100)
No
Iron deficiency is highly prevalent in heart failure patients and is associated with significantly elevated NT-pro BNP levels.
Answers are grounded in this paper and cite their sources.
Iron deficiency anemia was associated with higher NT-proBNP in HF; hypothesis-generating and requires prospective trials before practice change.
Objective: To assess the prevalence of nutritional of anemia in Heart Failure patients and its correlation with the serum levels of NT-pro BNP. Methods: This is a single-center retrospective observational study, conducted at a tertiary care hospital in south India. Patients admitted to hospital with clinical diagnosis of HF based on validated clinical criteria were included in the study. Anemia was dened as hemoglobin (Hb) <13 g/dl for males and <12 g/dl for females, based on World Health Organization denition. Anemia was classied based on complete Iron prole, including serum iron, serum ferritin, total iron binding capacity, and transferrin saturation (TSAT). Serum levels of Vit B12 and Folate also assayed. Plasma concentrations of NTpro-BNP levels were assessed and correlated with the above parameters. A total of 100 patients ofResults: HF (69% males and 31% females) were studied. Most of the patients were of high-functional NYHA class ( NYHA Class III 81%) and with Moderate LV systolic Dysfunction (44%). Iron Deciency (ID)anemia was present in 72% patients with 50.4% patients having absolute and 21.6% patients having functional ID. Females were having signicantly higher prevalence of ID than males (80.6% vs 68.1%; p = 0.002). The NTpro-BNP levels in patients with IDA were statistically signicant (with p<0.01) when compared to patients with normal iron levels . Conclusion: This study concludes that ID is much more common in patients with Heart Failure compared to Vit B12 or Folic acid deciency. The NTpro- BNP levels are elevated to much higher values in patients of heart failure with comorbid iron deciency states. Treating ID along with the routine heart failure management may improve the Quality of Life in HF patients.
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MR et al. (2022) conducted an observational in Heart Failure (n=100). Iron deficiency anemia vs. Normal iron levels was evaluated on NTpro-BNP levels (p=<0.01). Iron deficiency anemia was present in 72% of heart failure patients and was associated with significantly higher NTpro-BNP levels compared to patients with normal iron levels (P<0.01).
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