Population
63 acute ischemic stroke patients treated with IV t-PA thrombolysis at a single center in Japan, median age…
Design
Review
Follow-up
7 days
Key result
In patients with acute ischemic stroke treated with t-PA, a bad outcome at day 7 was significantly more frequent in those with a baseline DWI ASPECTS ≤6 (6 of 9 patients) compared to those with a score ≥7 (1 of 28 patients).
Authors
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Should not yet guide t-PA eligibility; leaves open DWI-ASPECTS thresholds for prospective selection trials.
Observational (n=37)
Absolute Event Rate: 66.7% vs 3.6%
p-value: p=<0.0001
In acute ischemic stroke patients treated with IV t-PA, a baseline DWI-ASPECTS > 5 is strongly associated with better neurological recovery, suggesting it can be used to select eligible patients.
Kazumi Kimura (2008) conducted an observational in acute ischemic stroke (n=37). Baseline DWI ASPECTS ≤6 vs. Baseline DWI ASPECTS ≥7 was evaluated on Bad clinical outcome at day 7 after t-PA therapy (p=<0.0001). In patients with acute ischemic stroke treated with t-PA, a bad outcome at day 7 was significantly more frequent in those with a baseline DWI ASPECTS ≤6 (6 of 9 patients) compared to those with a score ≥7 (1 of 28 patients).