Key result
In a cohort of 20 Thai patients with congenital long QT syndrome, pathogenic variants were predominantly identified in KCNQ1 (35%), KCNH2 (24%), and SCN5A (12%) families.
Population
20 children and young adults with congenital long QT syndrome in Thailand, 45% male, mean QTc 550.3 msec.
Design
Cohort
Authors
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Supports standard LQTS gene panels in Thai patients; leaves open validation in larger Southeast Asian cohorts.
Observational (n=20)
In a Thai cohort of children and young adults with congenital long QT syndrome, genetic mutations were predominantly found in LQT1, LQT2, and LQT3 genes, aligning with known global distributions.
Saprungruang et al. (2018) conducted an observational in Congenital long QT syndrome (n=20). Congenital long QT syndrome genotype was evaluated on Identification of pathogenic and likely pathogenic genetic variants. In a cohort of 20 Thai patients with congenital long QT syndrome, pathogenic variants were predominantly identified in KCNQ1 (35%), KCNH2 (24%), and SCN5A (12%) families.
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