Genetic testing for heritable cardiac arrhythmia syndromes allows the identification of at-risk family members and contributes to risk-stratification and selection of therapeutic interventions.
Genetic testing in heritable cardiac arrhythmia syndromes provides important diagnostic, prognostic, and therapeutic value, though careful interpretation of the signal-to-noise ratio is essential to identify true pathogenic variants.
PURPOSE OF REVIEW: In this review, we summarize the basic principles governing rare variant interpretation in the heritable cardiac arrhythmia syndromes, focusing on recent advances that have led to disease-specific approaches to the interpretation of positive genetic testing results. RECENT FINDINGS: Elucidation of the genetic substrates underlying heritable cardiac arrhythmia syndromes has unearthed new arrhythmogenic mechanisms and given rise to a number of clinically meaningful genotype-phenotype correlations. As such, genetic testing for these disorders now carries important diagnostic, prognostic, and therapeutic implications. Recent large-scale systematic studies designed to explore the background genetic 'noise' rate associated with these genetic tests have provided important insights and enhanced how positive genetic testing results are interpreted for these potentially lethal, yet highly treatable, cardiovascular disorders. SUMMARY: Clinically available genetic tests for heritable cardiac arrhythmia syndromes allow the identification of potentially at-risk family members and contribute to the risk-stratification and selection of therapeutic interventions in affected individuals. The systematic evaluation of the 'signal-to-noise' ratio associated with these genetic tests has proven critical and essential to assessing the probability that a given variant represents a rare pathogenic mutation or an equally rare, yet innocuous, genetic bystander.
Giudicessi et al. (2012) conducted a review in Heritable cardiac arrhythmia syndromes. Genetic testing was evaluated. Genetic testing for heritable cardiac arrhythmia syndromes allows the identification of at-risk family members and contributes to risk-stratification and selection of therapeutic interventions.