Letters to the Editor these patients and that it increases with weight gain.In conclusion, Eckfeldt and Freier have raised an interesting theoretical point regarding the low creatinine clearance in patients with anorexia nervosa.Our patients were, however, not ketotic and therefore Eckfeldt's and Freier's objection is not directly relevant.Furthermore, we are all too aware of the fallacies of basing indices of renal function on creatinine clearance,6 and have taken care to show that the true glomerular filtration rate based on clearance of edetic acid labelled with 5chromium is also diminished in these patients.
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RAB Drury (1985) studied this question.