Unfolding the Action of Progesterone Receptors

Progesterone regulates a plethora of biologically distinct processes in a broad range of tissues through the action of the progesterone receptor (PR).1 With the identification of PR target genes and membrane-associated PR, its actions span normal homeostatic functions and a wide variety of seemingly unlinked biological processes. In recent years, significant progress has been made in the molecular aspects of PR function. Intense interest in defining the action of progesterone has revealed important mechanisms involving multiple layers of regulation in transcription.