Key result
PDE4D3, but not PDE4D5, is recruited to the cardiac I(Ks) potassium channel via AKAP-9 and contributes to its critical regulation by cAMP.
PDE4D3 is a critical component of the cardiac I(Ks) potassium channel macromolecular complex, recruited via AKAP-9 to regulate the channel's response to cAMP.
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PDE4D3 selectivity may inform I(Ks) modulation strategies; leaves open translation to human arrhythmia therapies.
Terrenoire et al. (2009) studied this question. PDE4D3 vs. PDE4D5 was evaluated on Co-immunoprecipitation with I(Ks) channels and modulation of I(Ks) response to cAMP. PDE4D3, but not PDE4D5, is recruited to the cardiac I(Ks) potassium channel via AKAP-9 and contributes to its critical regulation by cAMP.
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