The clinical utility of dynamic ctDNA monitoring in inoperable localized NSCLC patients

In summary, we found that baseline ctNDA was highly correlated with disease stages, but it was a poor prognostic marker. In contrast, ctDNA collected 1 month post-CRT/RT was the optimal to predict patients’ PFS and OS, and the dynamic change in ctDNA was closely associated with clinical outcomes. Our results further expanded the clinical utility of ctDNA for the early estimation of prognosis and timely adjustment of treatment regimens in patients with inoperable localized NSCLC. Methods and materials used in our study are attached as Supplementary information.