Key result
Aging from 4 to 24 weeks in female rats was associated with markedly increased cardiac and extensor digitorum longus doxorubicin accumulation and reduced MRP-2 and MRP-7 expression.
Why the study?
Does age affect multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle in female Sprague-Dawley rats?
Population
Female Sprague-Dawley rats at various ages (4 to 24 weeks)
Comparison
Doxorubicin 15-mg/kg body weight bolus injection vs Comparison across different age groups
Design
Preclinical, randomly selected
Authors
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May heighten doxorubicin cardiotoxicity concerns with age in rat models; leaves open MRP-2/7 relevance for human anthracycline dosing.
Does age affect multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle in female Sprague-Dawley rats?
Aging is associated with increased doxorubicin accumulation in cardiac tissue, which may be driven by an age-related decrease in multidrug resistance protein expression.
Gibson et al. (2013) studied this question. Doxorubicin was evaluated on Age-related differences in muscle MRP expression and DOX accumulation. Aging from 4 to 24 weeks in female rats was associated with markedly increased cardiac and extensor digitorum longus doxorubicin accumulation and reduced MRP-2 and MRP-7 expression.
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