Key result
Peroxisome proliferator-activated receptor gamma agonists and glucocorticoids potently inhibited adipocyte-induced recruitment of macrophages in vitro and prevented ATM accumulation in vivo.
Population
In vitro adipocyte and macrophage models, and in vivo high fat diet-fed mice
Comparison
Peroxisome proliferator-activated receptor gamma… vs Control/untreated conditions
Design
Preclinical
Authors
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May attenuate adipose inflammation in obese animal models; leaves open human translation for metabolic disease.
PPAR gamma agonists and glucocorticoids inhibit adipocyte-mediated macrophage recruitment, suggesting a potential mechanism to reduce adipose tissue inflammation associated with obesity and insulin resistance.
Patsouris et al. (2009) studied Obesity-associated inflammation and type II diabetes. Peroxisome proliferator-activated receptor gamma agonists and glucocorticoids (dexamethasone) was evaluated on Adipocyte-induced recruitment of macrophages and adipose tissue macrophage (ATM) accumulation. Peroxisome proliferator-activated receptor gamma agonists and glucocorticoids potently inhibited adipocyte-induced recruitment of macrophages in vitro and prevented ATM accumulation in vivo.
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