Key result
Percutaneous mitral balloon valvuloplasty significantly decreased platelet distribution width from 13.5 fL to 12.4 fL at 1 month post-procedure in patients with rheumatic mitral stenosis.
Why the study?
Increased platelet activity and elevated MPV occur in rheumatic mitral stenosis, but PDW and the impact of PMBV on PDW had never been studied.
Does percutaneous mitral balloon valvuloplasty reduce platelet distribution width in symptomatic patients with severe rheumatic mitral stenosis?
Observational (n=30)
No
Does percutaneous mitral balloon valvuloplasty reduce platelet distribution width in symptomatic patients with severe rheumatic mitral stenosis?
Percutaneous mitral balloon valvuloplasty significantly decreases platelet distribution width, suggesting a reduction in platelet activity following the relief of rheumatic mitral stenosis.
Answers are grounded in this paper and cite their sources.
May suggest reduced platelet reactivity post-PMBV; hypothesis-generating for thrombotic risk in rheumatic mitral stenosis.
Aim: Increased platelet activity and elevated mean platelet volume (MPV) has been demonstrated in patients with rheumatic mitral stenosis (RMS). However, platelet distribution width (PDW) and the impact of percutaneous mitral balloon valvuloplasty (PMBV) on PDW has never been studied. Therefore, we aimed to investigate whether PMBV decreases PDW in patients with RMS.Material and Methods: Symptomatic patients with severe RMS undergoing PMBV were included. Echocardiographic characteristics and hematologic parameters was measured just before and 1 month after the PMBV procedure.Results: A total of 30 patients (24 female, mean age: 49.8±13.2 years) were included the study. Mean transmitral pressure gradient, pulmonary artery pressures and left atrium diameter decreased but mitral valve area increased significantly after PMBV. PMBV procedure significantly decreased PDW in patients with RMS (13.5±2.3 vs 12.4±1.9 fL, before and after procedure, respectively; p<0.0001). MPV was decreased after PMBV but it was not statistically significant (10.9±0.8 vs 10.6±0.9 fL, p=0.056). Platelet count was significantly increased after procedure (250±62.6 vs 273.5±78.6 x103/ul, p=0.035). In linear regression analysis, an independent relationship was found in magnitude of PDW decrease and magnitude of increase in mitral valve area (ẞ:0.491, p=0.046). Conclusion: PMBV is associated with a significant decrease in PDW 1 month after the procedure. There was a significant correlation between the magnitude of decrease in PDW and magnitude of increase in mitral valve area after PMBV.
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Tek et al. (2019) conducted an observational in Rheumatic mitral stenosis (n=30). Percutaneous mitral balloon valvuloplasty vs. Before procedure (baseline) was evaluated on Platelet distribution width (PDW) (p=<0.001). Percutaneous mitral balloon valvuloplasty significantly decreased platelet distribution width from 13.5 fL to 12.4 fL at 1 month post-procedure in patients with rheumatic mitral stenosis.
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