An Efficient One‐Pot Enantio‐ and Diastereoselective Synthesis of Heterocycles

Five- and six-membered nitrogen and oxygen heterocycles are accessible from two acyclic precursors in a one-pot reaction that comprises a Ru-catalyzed ene–yne addition followed by a Pd-catalyzed asymmetric allylic alkylation (see scheme). The stereochemistry of the products derives from the catalyst rather than from substrate control using chiral substrates.