Key result
A 5% CBD concentration liquid preparation yielded superior pharmacokinetic profiles, with fat free mass significantly predicting time to peak concentration (R2 = 0.365, p = 0.017).
Why the study?
Data supporting physiological effects of cannabidiol ingestion in humans are conflicting, potentially due to preparation differences and bioavailability, while the influence of body composition remains undocumented.
Does the type of oral cannabidiol preparation and body composition influence pharmacokinetics and heart rate variability in healthy adults?
RCT (n=15)
Crossover
Does the type of oral cannabidiol preparation and body composition influence pharmacokinetics and heart rate variability in healthy adults?
Cannabidiol bioavailability varies significantly by preparation type and is influenced by fat-free mass, with acute ingestion modestly affecting autonomic regulation of heart rate.
Answers are grounded in this paper and cite their sources.
5% CBD liquid may optimize bioavailability in healthy adults; extends PK data by linking fat-free mass to absorption timing.
Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are conflicting. Differences between CBD preparations and bioavailability may contribute to these discrepancies. Further, an influence of body composition on CBD bioavailability is feasible, but currently undocumented. The aims of this study were to: (1) compare the pharmacokinetics of five oral CBD preparations over 4 h; (2) examine the relationship between body composition and CBD pharmacokinetics; and, (3) explore the influence of CBD on heart rate variability. In total, five preparations of CBD, standardized to 30 mg, were orally administered to 15 healthy men and women (21–62 years) in a randomized, crossover design. Prior to and 60 min following CBD ingestion, heart rate variability was determined. Body composition was assessed using dual energy X-ray absorptiometry. Peak circulating CBD concentration, time to peak concentration, and area under the curve was superior in a preparation comprising 5% CBD concentration liquid. Fat free mass was a significant predictor (R2 = 0.365, p = 0.017) of time to peak concentration for this preparation. Several heart rate variability parameters, including peak frequency of the high frequency band, were favorably, but modestly modified following CBD ingestion. These data confirm an influence of CBD preparation and body composition on CBD bioavailability, and suggest that acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.
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Williams et al. (2021) conducted an RCT in Healthy (n=15). Oral cannabidiol (CBD) preparations vs. Other CBD preparations (crossover) was evaluated on Pharmacokinetics (peak circulating CBD concentration, time to peak concentration, and area under the curve). A 5% CBD concentration liquid preparation yielded superior pharmacokinetic profiles, with fat free mass significantly predicting time to peak concentration (R2 = 0.365, p = 0.017).
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