Key result
In Jurkat T cells, internal application of PIP2, PIP3, and external SDF-1alpha significantly reduced Kv1.3 potassium channel current activity.
Phosphoinositides and SDF-1alpha inhibit Kv1.3 potassium current in Jurkat T cells, suggesting a novel downregulation mechanism for T lymphocyte activation.
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Does not inform clinical practice; leaves open Kv1.3 regulation of T-cell activation for in vivo study.
Matsushita et al. (2009) studied Jurkat T cell line (in vitro). Phosphoinositides (PIP2, PIP3) and SDF-1alpha was evaluated on Kv1.3 current activity. In Jurkat T cells, internal application of PIP2, PIP3, and external SDF-1alpha significantly reduced Kv1.3 potassium channel current activity.
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