Schizophrenia is a neuropsychiatric disorder involving disturbances of perception, cognition, and behavior. It is associated with deficits in γ-aminobutyric acid (GABA) neurotransmission; clozapine, regarded as the most effective antipsychotic, is associated with potentiation of GABA. In this article, we describe the pharmacology of clozapine vis-à-vis schizophrenia, discuss current evidence linking clozapine to GABAergic neurotransmission, and highlight alternative treatment methods that may lead to improved outcomes through the GABAergic system. Clinical Pharmacology & Therapeutics (2009) 86 4, 442–446. doi:10.1038/clpt.2009.115
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Daskalakis et al. (2009) studied this question.
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