Why the study?
Does ACE inhibitor enalapril prevent the rise in glomerular cytokine expression induced by increased glomerular capillary pressure in uninephrectomized spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) subjected to uninephrectomy
Comparison
Angiotensin-converting enzyme inhibitor enalapril vs Uninephrectomized SHR without ACE inhibitor…
Design
Preclinical
Follow-up
Up to 4 weeks
Authors
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ACE inhibition prevents pressure-induced cytokine expression in rat glomeruli; hypothesis-generating for renoprotection in human hypertensive nephropathy.
Does ACE inhibitor enalapril prevent the rise in glomerular cytokine expression induced by increased glomerular capillary pressure in uninephrectomized spontaneously hypertensive rats?
An acute increase in glomerular capillary pressure leads to increased TGF-beta 1 and PDGF expression, which can be prevented by ACE inhibition with enalapril.
Shankland et al. (1994) studied this question.
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