Key result
Nuclear myosins are integral for cellular survival, playing key roles in transcription, DNA damage repair, chromatin organization, and viral infections.
Why the study?
Despite the involvement of nuclear myosins in fundamental cellular processes like transcription, DNA repair, and viral infections, understanding of these functions and their regulation remains limited.
This review highlights the integral roles of nuclear myosins in fundamental cellular processes such as transcription and DNA repair.
Nuclear myosin functions in transcription and repair merit cardiac cell investigation; leaves open disease relevance and therapeutic potential.
The myosin family of molecular motors are well-characterised cytoskeletal proteins. However, myosins are also present in the nucleus, where they have been shown to have roles in transcription, DNA repair and viral infections. Despite their involvement in these fundamental cellular processes, our understanding of these functions and their regulation remains limited. Recently, research on nuclear myosins has been gathering pace, and this Review will evaluate the current state of the field. Here, we will focus on the variation in structure of nuclear myosins, their nuclear import and their roles within transcription, DNA damage, chromatin organisation and viral infections. We will also consider both the biochemical and biophysical properties and restraints that are placed on these multifunctional motors, and how they link to their cytoplasmic counterparts. By highlighting these properties and processes, we show just how integral nuclear myosins are for cellular survival.
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Cook et al. (2020) reported a review. Nuclear myosins was evaluated. Nuclear myosins are integral for cellular survival, playing key roles in transcription, DNA damage repair, chromatin organization, and viral infections.
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