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September 1, 2012Current Protocols in Mouse Biology16 citations

Determination of Muscle Fiber Type in Rodents

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Population

Rodents (mouse hindlimbs)

Design

Preclinical

Authors

BKBernadett KalmárGBGonzalo BlancoLGLinda Greensmith

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Overview

Facilitates standardized fiber typing in mouse models; leaves open translation to human cardiovascular muscle pathology.

Structured PICO

P
Population
Rodents (mouse hindlimbs)
I
Intervention
Histological identification methods (staining for myosin ATPases, oxidative enzyme capacity/SDH, or immunostaining for specific myosin heavy chain isoforms)
O
Outcome
Identification of slow/type I, fast fatigue resistant/type IIa, and fast fatigable/type IIb fiberssurrogate

This protocol provides three methods for identifying muscle fiber types in mouse hindlimbs, useful for studying pathological changes in muscle composition.

Cite This Study

Kalmár et al. (2012) studied this question.

synapsesocial.com/papers/6a8864aeecbb6f2effa53d36https://doi.org/10.1002/9780470942390.mo110229
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