Why the study?
Can accelerated 3D MR tagging accurately quantify left ventricular dyssynchrony in patients with sub-acute myocardial infarctions compared to healthy controls?
Can accelerated 3D MR tagging accurately quantify left ventricular dyssynchrony in patients with sub-acute myocardial infarctions compared to healthy controls?
Accelerated 3D MR tagging can rapidly and accurately quantify left ventricular dyssynchrony and scar tissue, showing potential utility for cardiac resynchronization therapy planning.
Extends 3D tagging to post-MI dyssynchrony quantification; leaves open CRT selection utility pending prospective validation.
Cardiac resynchronization therapy (CRT) proved successful in larger patient populations. However, individual responsiveness to CRT is not yet highly predictable. Around 30% of patients do not appear to benefit from CRT [ 1 ]. Accurate measurement of dyssynchrony could help in discriminating CRT responders from non-responders. Individual responsiveness of patients could be improved with the knowledge of temporally resolved, regional motion patterns. The acquisition of multi-slice MR tagging data [ 2 ] covering the whole heart in short- and long axis orientations is associated with long acquisition times and prone to slice misregistration. A novel accelerated 3D tagging acquisition scheme [ 3 , 4 ] allows assessing detailed 3D motion patterns of the entire left ventricle (LV) in only three breath-holds. Accordingly, the method is easily integrated into a clinical protocol including volumetric, perfusion and viability measurements.
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Rutz et al. (2008) studied this question.
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