Biodegradable porous silica nanoparticles – Potential solutions in cancer treatment

Biodegradable porous silica nanoparticles (B-PMO) have been developed as a great promising in targeted drug delivery. In this review, we introduce our research for design, synthesis and development of B-PMO nanomaterials with biodegradable organic framework for anticancer drugs delivery applications. The biodegradable organic linker, incorporated into the structure, responds to the specific conditions in the tumor and then nanoparticles can be degraded and further eliminated from the body. The accumulation of NPs into tumor spheroid and inhibit of tumor growth were demonstrated. In particular, anticancer drug-loaded B-PMO inhibited the tumor growth in a chicken egg model and reduced significantly side effects toward the organs of the chicken embryo. The results of research and development of biodegradable-based silica nanomaterials show their potential in cancer treatment.