Molecular recognition between peptide β sheets is sequence selective! By simply controlling the placement of two threonine (Thr) or valine (Val) residues, peptides that preferentially form either homodimers or heterodimers with about tenfold selectivity can be generated. The picture shows the structure of a Thr–Val⋅Val–Thr heterodimer.
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Nowick et al. (2003) studied this question.
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