A semi‐empirical conformational energy calculation has been performed on the ionizable polydipeptide poly(Glu‐Ala). The results indicate that; (1)the ionized polymer assumes the lefthanded extended helix conformation is aqueous solution; (2) the poly(Glu‐Ala) extended helix is less stable than that of polyglutamic acid; (3) the unionized polydipeptide will preferentially assume the “β‐helical” conformation (isolated 2 1 degenerate helix) in aqueous solution. These conclusions are supported by experiment.
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Hiltner et al. (1973) studied this question.
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