Why the study?
Do ftorafur and 5-fluorouracil affect the inotropic and chronotropic responses in isolated canine sinoatrial nodes?
Population
Isolated sinoatrial node and atrial preparations obtained from puppies
Comparison
Ftorafur and 5-fluorouracil (5-FU) vs Solvent of 5-FU
Design
Preclinical
Authors
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Suggests direct cardiac stimulation by 5-FU agents in vitro; leaves open translation to human cardiotoxicity.
Do ftorafur and 5-fluorouracil affect the inotropic and chronotropic responses in isolated canine sinoatrial nodes?
Ftorafur and 5-fluorouracil induce positive inotropic and chronotropic effects in canine sinoatrial nodes, likely through direct action.
Satoh et al. (1983) studied this question.