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Inward permeation from the surrounding medium of phenobarbital through the wall of water-loaded ethylcellulose microcapsules was investigated as a function of capsule size under the conditions of constant total capsule volume and constant total capsule surface area. The experimental data obtained were analysed in terms of capsule wall density and drug partition coefficient. The drug permeability coefficients calculated according to an equation derived from Fick's first law of diffusion were found to increase with decreasing capsule size in both constant total capsule volume and constant total capsule surface area experiments. The wall density and the drug partition coefficient also exhibited the same trend. Based on these findings, it was concluded that the drug permeation through ethylcellulose microcapsule membrane occurs predominantly by a solution-diffusion mechanism.
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Uno et al. (1984) studied this question.
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