Key points are not available for this paper at this time.
Design
Editorial
Dual antiplatelet therapy is not recommended for stroke prevention in atrial fibrillation due to an increased risk of major hemorrhage.
Dear Editor We thank Dr Jolobe for his comments following our article on increasing incidence of chronic subdural haematoma in the elderly.1 There is indeed no role for dual antiplatelets (aspirin and clopidogrel) for thromboprophylaxis in atrial fibrillation. Even though one study showed reduced rate of ischaemic stroke with clopidogrel plus aspirin, as compared with aspirin alone among patients with atrial fibrillation in patients considered unsuitable for a vitamin K antagonist, there was a significant increase in the risk of major haemorrhage.2 Since dual antiplatelet therapy is not recommended in any guidelines for stroke prevention in atrial fibrillation and is not part of clinical practice, we didn’t think it needed mentioning.
No takes yet. Share an insight, caveat, or question.
Adhiyaman et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: