X-rays can serve as an effective trigger to release doxorubicin from gold nanoparticle carriers via reactive oxygen species generation, enhancing targeted cellular toxicity.
X-ray-triggered doxorubicin release from nanoparticles is hypothesis-generating in animals; clinical translation remains untested.
Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.
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Starkewolf et al. (2013) studied this question.
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