The influence of rebreathing time when using a CO 2 rebreathing method for graphical determination of the mixed venous CO 2 tension was studied. An almost significant difference of 0.6 mm was found between values obtained at rebreathing rates of 30 and 50 breaths per min with rebreathing times of 22 and 13 sec. This should give a difference at rest of about 5 per cent when the cardiac output is calculated, with the higher value when the fast rate is used for the mixed venous CO 2 determination. The solubility of CO 2 in lung tissue probably doses not cause this difference.
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Lundin et al. (1965) studied this question.
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