October 1, 1993European Journal of BiochemistryOpen Access

Aortic smooth muscle contains guanylate‐cyclase‐coupled 130‐kDa atrial natriuretic factor receptor as predominant receptor form

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Bovine aortic smooth muscle tissue, cultured smooth muscle cells from bovine aorta, bovine adrenal cortex, and lung membranes

Intervention

Photoaffinity labeling, peptide mapping, Northern blot analysis, and endoglycosidase treatment

Comparator

In vivo tissue vs. cultured cells

Outcome

Identification of ANF receptor forms (130-kDa vs 60-kDa) and guanylate cyclase activitysurrogate

The study demonstrates that the 130-kDa guanylate-cyclase-coupled ANF receptor is the predominant form in vivo in vascular smooth muscle, and that cell culturing artificially induces the 60-kDa C-receptor.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Caution against relying on cultured cell models for ANF receptor studies; leaves open the in vivo functional dominance of the 130-kDa receptor.

Cite This Study

Abe et al. (1993) studied this question.

synapsesocial.com/papers/6a8878edf9cabcdfeb4a6f2d https://doi.org/10.1111/j.1432-1033.1993.tb18246.x

View Full Paper

Ask AI

Bookmark

Implication

Caution against relying on cultured cell models for ANF receptor studies; leaves open the in vivo functional dominance of the 130-kDa receptor.

Aortic smooth muscle contains guanylate‐cyclase‐coupled 130‐kDa atrial natriuretic factor receptor as predominant receptor form

Structured PICO

Discussion

Implication

Cite This Study

Aortic smooth muscle contains guanylate‐cyclase‐coupled 130‐kDa atrial natriuretic factor receptor as predominant receptor form

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider