Why the study?
Is plasma BNP upon admission associated with short-term mortality after intracerebral hemorrhage?
Is plasma BNP upon admission associated with short-term mortality after intracerebral hemorrhage?
Elevated plasma BNP upon admission (>60.0 pg/ml) serves as a biological marker predicting short-term mortality in patients with intracerebral hemorrhage.
May support short-term risk stratification after ICH; leaves open whether BNP should guide management or requires prospective validation.
BACKGROUND AND PURPOSE: The purpose of the present study was to test the hypothesis that plasma brain natriuretic peptide (BNP) is associated with short-term mortality after intracerebral hemorrhage (ICH). METHODS: We prospectively enrolled 271 patients (median age 72 years; 109 females) who were admitted within 24 h of ICH onset between April 2007 and July 2011 and in whom plasma BNP levels were measured upon admission. The patients were assigned to two groups according to survival within 1 month of ICH. Factors associated with mortality were determined by multivariate logistic regression analysis. RESULTS: Within 1 month of ICH, 48 (17.7%) of the 271 enrolled patients died. The median (interquartile range) level of plasma BNP was significantly higher in the group of non-survivors than in the group of survivors [102.5 (48.7-205.0) vs. 32.4 (17.3-85.0) pg/ml; p < 0.001]. A cutoff BNP level of 60.0 pg/ml could predict death within 1 month of ICH. Multivariate logistic regression analysis showed that a plasma BNP of >60.0 pg/ml (OR 4.7; 95% CI 1.43-15.63; p = 0.011) was independently associated with mortality within 1 month after ICH. CONCLUSIONS: A high BNP level upon admission is associated with mortality within 1 month after ICH.
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Goya et al. (2014) studied this question.
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