Answers are grounded in this paper and cite their sources.
Two cases are presented which illustrate the dangers inherent in utilizing a polypharmacy approach in treating children with psychotropic medication. In each case, severe adverse effects, including cognitive and mood deterioration, were experienced by the child when treated with a combination of methylphenidate and imipramine. Possible mechanisms at the neurotransmitter level are described as postulated determinants for this pharmacological interaction.
No takes yet. Share an insight, caveat, or question.
Grob et al. (1986) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: