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October 31, 2017Science SignalingOpen Access

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

María José Sandí Christopher B. Marshall Marc Balan Étienne Coyaud Ming Zhou Daniel M. Monson Noboru Ishiyama Arun A. Chandrakumar José La Rose Amber L. Couzens Anne‐Claude Gingras Brian Raught Wei Xu Mitsuhiko Ikura Deborah K. Morrison Robert Rottapel

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Abstract

in ARHGEF2 to restore the inhibited state. Thus, we have identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2.

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Sandí et al. (2017) studied this question.

synapsesocial.com/papers/6a887b800562fa470f4a7a74 https://doi.org/10.1126/scisignal.aan3286

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedOriginal Research · 1995 · 1,122 citations
2The regulation and function of mammalian AMPK‐related kinasesReview · 2009 · 196 citations
3Identification of genes required for cytoplasmic localization in early C. elegans embryosOriginal Research · 1988 · 859 citations
4MARK4 Is a Novel Microtubule-associated Proteins/Microtubule Affinity-regulating Kinase That Binds to the Cellular Microtubule Network and to CentrosomesOriginal Research · 2004 · 189 citations
5Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarityOriginal Research · 2006 · 159 citations

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MARK2/EMK1/Par-1Bα Phosphorylation of Rab11-Family Interacting Protein 2 Is Necessary for the Timely Establishment of Polarity in Madin-Darby Canine Kidney Cells2006

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