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December 1, 1994Journal of Biological ChemistryOpen Access

Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter through CCAAT/enhancer binding protein (C/EBP).

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Authors

RORichard M. O’BrienVanderbilt UniversityPLPeter C. LucasUniversity of PittsburghTYTetsuhiro YamasakiFukushima Medical University

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O’Brien et al. (1994) studied this question.

synapsesocial.com/papers/6a88eabb3d6e0fcd7a28b191https://doi.org/10.1016/s0021-9258(18)43830-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS1989 · 1,269 citations
  2. 2Inhibition by insulin of protein kinase A-induced transcription of the phosphoenolpyruvate carboxykinase gene. Mediation by the activation domain of cAMP response element-binding protein (CREB) and factors bound to the TATA box.1994 · 28 citations
  3. 3Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).1993 · 192 citations
  4. 4CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.1993 · 371 citations
  5. 5Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription1990 · 371 citations