good evidence that such immunity occurs and may reduce symptoms or even prevent colonisation.25 The relation of serum concentrations of antibodies and immunity has yet to be established, though immunity may be mediated by IgG.26 The value of epidemiological studies would be greatly enhanced if investigators documented the serological anti- body status of cases and controls and if more reliable and convenient methods of identifying immunity were available.
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Norman Begg (1992) studied this question.
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