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The mechanisms whereby dietary sodium restriction leads to decreased arterial blood pressure is obscure. Previously reported studies of patients with arterial hypertension showed a lessened pressor response to norepinephrine after sodium restriction. In the present investigations, reduction in pressor response to norepinephrine during the low sodium period was observed only occasionally; sodium restriction decreases blood pressure in some hypertensive patients by other unknown mechanisms.
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Lewis K. Dahl (1957) studied this question.
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