The changes in the electrolyte composition of ar- terial wall in renal and desoxycorticosterone in- duced hypertension (1) have stimulated us to in- vestigate the changes in the electrolytes of arterial smooth muscle that occur when an artery is brought under the influence of nor-epinephrine. The effects of this particular substance are es- pecially important since present evidence indicates that it is the main sympathetic neurohumoral agent affecting the peripheral arterial system. This study was first attempted with arterial rings in vitro using the Krebs-Henseleit medium. In this medium the control arteries lost large amounts of potassium, a situation which prompted an in vivo approach.
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Tobian et al. (1956) studied this question.