The enantioselective propargylic alkylation of propargylic alcohols with β-keto phosphonates in the presence of a thiolate-bridged diruthenium complex and a copper complex as cocatalysts gives the corresponding propargylic alkylated products in excellent yields with high diastereo- and enantioselectivities (up to 97% ee).
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Motoyama et al. (2012) studied this question.
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